Research Projects

Different ongoing research projects aim to address following key questions:

  • Cell signaling to chromatin and how this interplay impacts cell memory. It involves developing assays which will facilitate identification and analysis of novel factors involved in epigenetic cell memory.
  • Molecular signatures of epigenetic factors involved in cell memory. It involves an effort to characterize kinetics of epigenetic factors and a structure to function approach is being applied to link biochemical analysis with physiological relevance.
  • Adaptation and evolution of new traits. We have recently reported that starvation induces cannibalistic behaviour in Drosophila (Scientific Reports 2015). Ongoing reserach in our laboratory aims to develop new assays to ultimately find molecular basis of new traits evolved in response to environmental stimuli.
  • Role of molecular chaperones in epigenetic gene regulation by PcG/TrxG genes

Our lab uses genetics, molecular biology and biochemical tools to achieved objectives of above mentioned projects. We also collaborate with Dr. Aziz Mithani and Dr. Safee Ullah to understand system biological aspects of our ongoing reserach and develop new avenues which may help us understand epigenetics of cell memory at a systems level.

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